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Article

The Outcome of the Cryptococcus neoformans-Macrophage Interaction Depends on Phagolysosomal Membrane Integrity.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2018

De Leon-Rodriguez Carlos M, Rossi Diego C P, Fu Man Shun, Dragotakes Quigly, Coelho Carolina, Guerrero Ros Ignacio, Caballero Benjamin, Nolan Sabrina J, Casadevall Arturo

Abstract excerpt

Cryptococcus neoformans is a fungal pathogen with worldwide distribution. C. neoformans resides within mature phagolysosomes where it often evades killing and replicates. C. neoformans induces phagolysosomal membrane permeabilization (PMP), but the mechanism for this phenomenon and its consequences for macrophage viability are unknown. In this study, we used flow cytometry methodology in combination with cell...

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Identifiers

PMID: 29858266
DOI: 10.4049/jimmunol.1700958
PMCID: PMC6245949

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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