Article
DOPAL is transmissible to and oligomerizes alpha-synuclein in human glial cells.
Autonomic neuroscience : basic & clinical - 1 Jan 2016
Jinsmaa Yunden, Sullivan Patricia, Sharabi Yehonatan, Goldstein David S
Abstract excerpt
INTRODUCTION: Glial cytoplasmic inclusions (GCIs) containing alpha-synuclein (AS) are a neuropathologic hallmark of multiple system atrophy (MSA). Oligomerized AS is thought to be the pathogenic form of the protein. Glial cells normally express little AS, but they can take up AS from the extracellular fluid. 3,4-Dihydroxyphenylacetaldehyde (DOPAL), an obligate intermediate in the intra-neuronal metabolism of...
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