Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abundant glial alpha-synuclein pathology in a case without overt clinical symptoms.

Clinical neuropathology - 1 Jan 2000

Parkkinen L, Hartikainen P, Alafuzoff I

Abstract excerpt

Screening of 1,800 brains with alpha-synuclein (alphaS) immunohistochemistry revealed five cases with abundant glial cytoplasmic inclusions (GCIs) within the white matter of the brainstem. Surprisingly, retrospective clinical assessment showed that one of these subjects did not fulfil the currently recommended clinical consensus criteria for the multiple system atrophy (MSA). One of the hallmark lesions of MSA,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to alpha-Synuclein
Share to Inclusion Bodies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Multiple System Atrophy

Share to Neuroglia

Share to Phenotype

Source

Identifiers

PMID: 18232593
DOI: 10.5414/npp26276

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abundant glial alpha-synuclein pathology in a case without overt clinical symptoms.PMID 18232593Read ↗

α-Synuclein immunoreactivity in glial cytoplasmic inclusions in multiple system atrophySemantic proximity Read ↗

Neuronal α-synuclein toxicity is the key driver of neurodegeneration in multiple system atrophySemantic proximity Read ↗

Multiple system atrophy: genetic risks and alpha-synuclein mutationsSemantic proximity Read ↗

Immunohistochemical and Biochemical Studies Demonstrate a Distinct Profile of α-Synuclein Permutations in Multiple System AtrophySemantic proximity Read ↗

Heterogeneity of Multiple System Atrophy: An UpdateSemantic proximity Read ↗

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disordersSemantic proximity Read ↗

Alpha‐synuclein mRNA expression in oligodendrocytes in MSASemantic proximity Read ↗

N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s diseaseSemantic proximity Read ↗

Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synucleinSemantic proximity Read ↗

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism.Semantic proximity Read ↗

The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations.Semantic proximity Read ↗

Absence of α-synuclein mRNA expression in normal and multiple system atrophy oligodendrogliaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.