Article
Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease.
BMC genomics - 2 Sept 2024
Konigsberg Iain R, Vu Thao, Liu Weixuan, Litkowski Elizabeth M, Pratte Katherine A, Vargas Luciana B, Gilmore Niles, Abdel-Hafiz Mohamed, Manichaikul Ani, Cho Michael H, Hersh Craig P, DeMeo Dawn L, Banaei-Kashani Farnoush, Bowler Russell P, Lange Leslie A, Kechris Katerina J
Abstract excerpt
BACKGROUND: Studies have identified individual blood biomarkers associated with chronic obstructive pulmonary disease (COPD) and related phenotypes. However, complex diseases such as COPD typically involve changes in multiple molecules with interconnections that may not be captured when considering single molecular features. METHODS: Leveraging proteomic data from 3,173 COPDGene Non-Hispanic White (NHW) and...
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