Systemic DNA damage responses in aging and diseases.

doi:10.1016/j.semcancer.2015.12.005

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Article

Systemic DNA damage responses in aging and diseases.

Seminars in cancer biology - 1 Jun 2016

Ribezzo Flavia, Shiloh Yosef, Schumacher Björn

Abstract excerpt

The genome is constantly attacked by a variety of genotoxic insults. The causal role for DNA damage in aging and cancer is exemplified by genetic defects in DNA repair that underlie a broad spectrum of acute and chronic human disorders that are characterized by developmental abnormalities, premature aging, and cancer predisposition. The disease symptoms are typically tissue-specific with uncertain...

Topics

Aging
Animals
Cellular Senescence
DNA Breaks, Double-Stranded
DNA Damage
DNA Repair
Genetic Association Studies
Genomic Instability
Humans
Immunity, Innate
Mutation
Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 26773346
DOI: 10.1016/j.semcancer.2015.12.005
PMCID: PMC4886830

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