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Article

The role of common variants of ABCB1, CYP3A4, and CYP3A5 genes in lipid-lowering efficacy and safety of simvastatin treatment.

Clinical pharmacology and therapeutics - 1 Nov 2005

Fiegenbaum Marilu, da Silveira Fabiano R, Van der Sand Cézar R, Van der Sand Luiz Carlos, Ferreira Maria E W, Pires Renan C, Hutz Mara H

Abstract excerpt

OBJECTIVE: Our objective was to investigate the interactions between common polymorphisms in ABCB1, CYP3A4, and CYP3A5 genes and the lipid-lowering efficacy and safety of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin. METHODS: One hundred sixteen hypercholesterolemic patients were prospectively screened by physical examination, medical history, and clinical laboratory evaluation and...

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Source

Identifiers

PMID: 16321621
DOI: 10.1016/j.clpt.2005.08.003

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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