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Article

Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis C

29 Jan 2013

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Share to Hepatitis C virus research
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Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 23358218
DOI: 10.1038/ng.2537

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Loss of function of the new interferon IFN-λ4 may confer protection from hepatitis CPMID 23358218Read ↗

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genesSemantic proximity Read ↗

A variant upstream of IFNL3 (IL28B) creating a new interferon gene IFNL4 is associated with impaired clearance of hepatitis C virusSemantic proximity Read ↗

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronavirusesSemantic proximity Read ↗

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Interferon lambda 4 expression is suppressed by the host during viral infectionSemantic proximity Read ↗

Conserved induction of distinct antiviral signalling kinetics by primate interferon lambda 4 proteinsSemantic proximity Read ↗

IFN-λ4 Attenuates Antiviral Responses by Enhancing Negative Regulation of IFN Signaling.Semantic proximity Read ↗

Interferon-lambda and therapy for chronic hepatitis C virus infection.Semantic proximity Read ↗

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The IFNL4 Gene Is a Noncanonical Interferon Gene with a Unique but Evolutionarily Conserved RegulationSemantic proximity Read ↗

Expression of Interferon Lambda 4 Is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic CellsSemantic proximity Read ↗

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