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Article

DNA co-methylation modules in postmortem prefrontal cortex tissues of European Australians with alcohol use disorders

14 Jan 2016

Abstract excerpt

DNA methylome alterations in the prefrontal cortex (PFC) may contribute to risk for alcohol use disorders (AUDs). We examined postmortem PFC DNA methylomes of 16 male and seven female pairs of AUD and control subjects using Illumina's HumanMethylation450 BeadChip assays. In male AUD subjects, 1,812 CpGs (1,099 genes) were differentially methylated (9.5 × 10(-9) ≤ Pnominal ≤ 7.2 × 10(-4), q < 0.05). In females, no...

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PMID: 26763658
DOI: 10.1038/srep19430

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