Article
GENESIS: a French national resource to study the missing heritability of breast cancer.
BMC cancer - 12 Jan 2016
Sinilnikova Olga M, Dondon Marie-Gabrielle, Eon-Marchais Séverine, Damiola Francesca, Barjhoux Laure, Marcou Morgane, Verny-Pierre Carole, Sornin Valérie, Toulemonde Lucie, Beauvallet Juana, Le Gal Dorothée, Mebirouk Noura, Belotti Muriel, Caron Olivier, Gauthier-Villars Marion, Coupier Isabelle, Buecher Bruno, Lortholary Alain, Dugast Catherine, Gesta Paul, Fricker Jean-Pierre, Noguès Catherine, Faivre Laurence, Luporsi Elisabeth, Berthet Pascaline, Delnatte Capucine, Bonadona Valérie, Maugard Christine M, Pujol Pascal, Lasset Christine, Longy Michel, Bignon Yves-Jean, Adenis Claude, Venat-Bouvet Laurence, Demange Liliane, Dreyfus Hélène, Frenay Marc, Gladieff Laurence, Mortemousque Isabelle, Audebert-Bellanger Séverine, Soubrier Florent, Giraud Sophie, Lejeune-Dumoulin Sophie, Chevrier Annie, Limacher Jean-Marc, Chiesa Jean, Fajac Anne, Floquet Anne, Eisinger François, Tinat Julie, Colas Chrystelle, Fert-Ferrer Sandra, Penet Clotilde, Frebourg Thierry, Collonge-Rame Marie-Agnès, Barouk-Simonet Emmanuelle, Layet Valérie, Leroux Dominique, Cohen-Haguenauer Odile, Prieur Fabienne, Mouret-Fourme Emmanuelle, Cornélis François, Jonveaux Philippe, Bera Odile, Cavaciuti Eve, Tardivon Anne, Lesueur Fabienne, Mazoyer Sylvie, Stoppa-Lyonnet Dominique, Andrieu Nadine
Abstract excerpt
BACKGROUND: Less than 20% of familial breast cancer patients who undergo genetic testing for BRCA1 and BRCA2 carry a pathogenic mutation in one of these two genes. The GENESIS (GENE SISter) study was designed to identify new breast cancer susceptibility genes in women attending cancer genetics clinics and with no BRCA1/2 mutation. METHODS: The study involved the French national network of family cancer clinics....
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