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Variants of cancer susceptibility genes in Korean BRCA1/2 mutation-negative patients with high risk for hereditary breast cancer.

BMC cancer - 16 Jan 2018

Park Ji Soo, Lee Seung-Tae, Nam Eun Ji, Han Jung Woo, Lee Jung-Yun, Kim Jieun, Kim Tae Il, Park Hyung Seok

Abstract excerpt

BACKGROUND: We evaluated the incidence and spectrum of pathogenic and likely pathogenic variants of cancer susceptibility genes in BRCA1/2 mutation-negative Korean patients with a high risk for hereditary breast cancer using a comprehensive multigene panel that included 35 cancer susceptibility genes. METHODS: Samples from 120 patients who were negative for BRCA1/2 mutations, but had been diagnosed with breast...

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Identifiers

PMID: 29338689
DOI: 10.1186/s12885-017-3940-y
PMCID: PMC5769462

Genes

BRCA1
PALB2
BARD1
BRIP1

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