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Genetic risk assessment and prevention: the role of genetic testing panels in breast cancer.

Expert review of anticancer therapy - 1 Jan 2015

Lerner-Ellis Jordan, Khalouei Sam, Sopik Victoria, Narod Steven A

Abstract excerpt

Multigene panel tests are being increasingly used for the genetic assessment of women with an apparent predisposition to breast cancer. Here, we review all studies reporting results from individuals who have undergone multigene panel testing for hereditary breast cancer. Across all gene panel studies, the prevalence of pathogenic mutations was highest in BRCA1 (5.3%) and BRCA2 (3.6%) and was lowest in PTEN...

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BRCA1 Protein
BRCA2 Protein
Breast Neoplasms
Checkpoint Kinase 2
Fanconi Anemia Complementation Group N Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Nuclear Proteins

Risk Assessment

Tumor Suppressor Proteins

Source

Identifiers

PMID: 26523341
DOI: 10.1586/14737140.2015.1090879

Genes

BRCA1
ATM
BRCA2
CHEK2
PALB2
CDH1
PTEN
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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