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Prophage-Stimulated Toxin Production in Clostridium difficile NAP1/027 Lysogens

27 Mar 2011

Abstract excerpt

TcdA and TcdB exotoxins are the main virulence factors of Clostridium difficile, one of the most deadly nosocomial pathogens. Recent data suggest that prophages can influence the regulation of toxin expression. Here we present the characterization of ϕCD38-2, a pac-type temperate Siphoviridae phage that stimulates toxin expression when introduced as a prophage into C. difficile. Host range analysis showed that...

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PMID: 21441508
DOI: 10.1128/jb.00787-10

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