Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy.

Cytokine - 1 Nov 2011

Napolioni Valerio, Carpi Francesco M, Giannì Paola, Sacco Roberto, Di Blasio Luca, Mignini Fiorenzo, Lucarini Nazzareno, Persico Antonio M

Abstract excerpt

Aging is a complex phenotype with multiple determinants but a strong genetic component significantly impacts on survival to extreme ages. The dysregulation of immune responses occurring with increasing age is believed to contribute to human morbidity and mortality. Conversely, some genetic determinants of successful aging might reside in those polymorphisms for the immune system genes regulating immune responses....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Deaminase
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Primers

Share to Epistasis, Genetic

Share to Life Expectancy

Share to Polymerase Chain Reaction

Share to Tumor Necrosis Factor-alpha

Share to Young Adult

Source

Identifiers

PMID: 21865054
DOI: 10.1016/j.cyto.2011.07.023

Genes

ADA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Age- and gender-specific epistasis between ADA and TNF-α influences human life-expectancy.PMID 21865054Read ↗

Gender-specific association of ADA genetic polymorphism with human longevity.Semantic proximity Read ↗

Inflamm-Aging, Cytokines and Aging: State of the Art, New Hypotheses on the Role of Mitochondria and New Perspectives from Systems BiologySemantic proximity Read ↗

Association of longevity with TNF-α G308A and IL-6 G174C polymorphic inflammatory biomarkers in Caucasians: a meta-analysis.Semantic proximity Read ↗

14th International HLA and Immunogenetics Workshop: report on the immunogenetics of aging.Semantic proximity Read ↗

Evidence from case-control and longitudinal studies supports associations of genetic variation in APOE, CETP, and IL6 with human longevity.Semantic proximity Read ↗

Genetic variant of Interleukin-18 gene is associated with the Frailty Index in the English Longitudinal Study of Ageing.Semantic proximity Read ↗

Immunogenetics, Gender, and LongevitySemantic proximity Read ↗

Detecting polymorphisms in human longevity studies: HLA typing and SNP genotyping by amplicon sequencing.Semantic proximity Read ↗

Neuroinflammation and Ageing: Current Theories and an Overview of the DataSemantic proximity Read ↗

TNFA gene variants related to the inflammatory status and its association with cellular aging: From the CORDIOPREV study.Semantic proximity Read ↗

Association between genetic variations in the insulin/insulin-like growth factor (Igf-1) signaling pathway and longevity: a systematic review and meta-analysis.Semantic proximity Read ↗

The Genetics of Human LongevitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.