Article

Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL) : surplus to requirements or a protagonist in lymphomagenesis?

2018-01-01

Abstract excerpt

Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin 1(NPM)-ALK, which is considered the main driver. ALCL have an unusual immunophenotype; they rarely express a T cell rece...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4be3a3aa-810d-52ec-965b-6e33552ac968
DOI: 10.17863/cam.20257

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL) : surplus to requirements or a protagonist in lymphomagenesis?DOI 10.17863/cam.20257Read

Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egressSemantic proximity Read

An Exploration into the Origins and Pathogenesis of Anaplastic Large Cell Lymphoma, Anaplastic Lymphoma Kinase (ALK)-positiveSemantic proximity Read

ALCL by any other name: the many facets of anaplastic large cell lymphoma.Semantic proximity Read

Gene expression profiling of isolated tumour cells from anaplastic large cell lymphomas: insights into its cellular origin, pathogenesis and relation to Hodgkin lymphoma.Semantic proximity Read

Anaplastic lymphoma kinase: signalling in development and diseaseSemantic proximity Read

ALK-positive anaplastic large cell lymphoma an evolving storySemantic proximity Read

Molecular Screening in Anaplastic Lymphoma Kinase–Positive Anaplastic Large Cell Lymphoma: Anaplastic Lymphoma Kinase Analysis, Next-Generation Sequencing Fusion Gene Detection, and T-Cell Receptor ImmunoprofilingSemantic proximity Read

Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell LymphomaSemantic proximity Read

Anaplastic large cell lymphoma: pathology, genetics, and clinical aspects.Semantic proximity Read

Genetics of anaplastic large cell lymphoma.Semantic proximity Read

De novo generation of the NPM-ALK fusion recapitulates the pleiotropic phenotypes of ALK+ ALCL pathogenesis and reveals the ROR2 receptor as target for tumor cells.Semantic proximity Read

The emerging pathogenic and therapeutic importance of the anaplastic lymphoma kinase gene.Semantic proximity Read