Article
Prolyl isomerase Pin1 promotes survival in EGFR-mutant lung adenocarcinoma cells with an epithelial-mesenchymal transition phenotype.
Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2016
Sakuma Yuji, Nishikiori Hirotaka, Hirai Sachie, Yamaguchi Miki, Yamada Gen, Watanabe Atsushi, Hasegawa Tadashi, Kojima Takashi, Niki Toshiro, Takahashi Hiroki
Abstract excerpt
The secondary epidermal growth factor receptor (EGFR) T790M mutation is the most prominent mechanism that confers resistance to first- or second-generation EGFR tyrosine kinase inhibitors (TKIs) in lung cancer treatment. Although third-generation EGFR TKIs can suppress the kinase activity of T790M-positive EGFR, they still cannot eradicate EGFR-mutated cancer cells. We previously reported that a subpopulation of...
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