Article
An activation of LC3A-mediated autophagy contributes to de novo and acquired resistance to EGFR tyrosine kinase inhibitors in lung adenocarcinoma.
The Journal of pathology - 1 Oct 2014
Nihira Kaito, Miki Yasuhiro, Iida Shinya, Narumi Sodai, Ono Katsuhiko, Iwabuchi Erina, Ise Kazue, Mori Kazushige, Saito Mikiyoshi, Ebina Masahito, Sato Ikuro, Maemondo Makoto, Yamada-Okabe Hisafumi, Kondo Takashi, Sasano Hironobu
Abstract excerpt
The development of therapeutic resistance to EGFR tyrosine kinase inhibitors (EGFR-TKIs, ie erlotinib or gefitinib) has been the major clinical problem when treating lung adenocarcinoma patients with these agents. However, its mechanisms have not necessarily been well studied to this date. Autophagy has been recently considered to play pivotal roles in escaping from the effects of anti-neoplastic agents....
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