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Article

Reduced Glucose Sensation Can Increase the Fitness of Saccharomyces cerevisiae Lacking Mitochondrial DNA.

PloS one - 1 Jan 2016

Akdoğan Emel, Tardu Mehmet, Garipler Görkem, Baytek Gülkız, Kavakli İ Halil, Dunn Cory D

Abstract excerpt

Damage to the mitochondrial genome (mtDNA) can lead to diseases for which there are no clearly effective treatments. Since mitochondrial function and biogenesis are controlled by the nutrient environment of the cell, it is possible that perturbation of conserved, nutrient-sensing pathways may successfully treat mitochondrial disease. We found that restricting glucose or otherwise reducing the activity of the...

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Identifiers

PMID: 26751567
DOI: 10.1371/journal.pone.0146511
PMCID: PMC4709096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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