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Respiratory and TCA cycle activities affect S. cerevisiae lifespan, response to caloric restriction and mtDNA stability.

Journal of bioenergetics and biomembranes - 1 Oct 2011

Tahara Erich B, Cezário Kizzy, Souza-Pinto Nadja C, Barros Mario H, Kowaltowski Alicia J

Abstract excerpt

We studied the importance of respiratory fitness in S. cerevisiae lifespan, response to caloric restriction (CR) and mtDNA stability. Mutants harboring mtDNA instability and electron transport defects do not respond to CR, while tricarboxylic acid cycle mutants presented extended lifespans due to CR. Interestingly, mtDNA is unstable in cells lacking dihydrolipoyl dehydrogenase under CR conditions, and cells...

Topics

Citric Acid Cycle
DNA, Fungal
DNA, Mitochondrial
Dihydrolipoamide Dehydrogenase
Mutation
Oxygen Consumption
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 21833600
DOI: 10.1007/s10863-011-9377-0

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