Article
BRAF V600E inhibition stimulates AMP-activated protein kinase-mediated autophagy in colorectal cancer cells.
Scientific reports - 11 Jan 2016
Sueda Toshinori, Sakai Daisuke, Kawamoto Koichi, Konno Masamitsu, Nishida Naohiro, Koseki Jun, Colvin Hugh, Takahashi Hidekazu, Haraguchi Naotsugu, Nishimura Junichi, Hata Taishi, Takemasa Ichiro, Mizushima Tsunekazu, Yamamoto Hirofumi, Satoh Taroh, Doki Yuichiro, Mori Masaki, Ishii Hideshi
Abstract excerpt
Although BRAF(V600E) mutation is associated with adverse clinical outcomes in patients with colorectal cancer (CRC), response and resistance mechanisms for therapeutic BRAF(V600E) inhibitors remains poorly understood. In the present study, we demonstrate that selective BRAF(V600E) inhibition activates AMP-activated protein kinase (AMPK), which induces autophagy as a mechanism of therapeutic resistance in human...
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