Article
Oncogenic RAS-induced downregulation of ATG12 is required for survival of malignant intestinal epithelial cells.
Autophagy - 1 Jan 2018
Yoo Byong Hoon, Khan Iman Aftab, Koomson Ananda, Gowda Pramod, Sasazuki Takehiko, Shirasawa Senji, Gujar Shashi, Rosen Kirill V.
Abstract excerpt
Activating mutations of RAS GTPase contribute to the progression of many cancers, including colorectal carcinoma. So far, attempts to develop treatments of mutant RAS-carrying cancers have been unsuccessful due to insufficient understanding of the salient mechanisms of RAS signaling. We found that RAS downregulates the protein ATG12 in colon cancer cells. ATG12 is a mediator of autophagy, a process of degradation...
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