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Article

BRAF V600E-dependent role of autophagy in uveal melanoma.

Journal of cancer research and clinical oncology - 1 Mar 2017

Zhao Yinu, Wang Weibin, Min Irene, Wyrwas Brian, Moore Maureen, Zarnegar Rasa, Fahey Thomas J

Abstract excerpt

BACKGROUND: Autophagy can function in a dual role in cancer development and progression: It can be cytoprotective or contribute to cell death. Therefore, determining the contextual role of autophagy between these two opposing effects is important. So far, little is known about the role of autophagy in uveal melanoma. In the present study, we looked to investigate the autophagic process, as well as its effect on...

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Autophagy
Indoles
Macrolides
Melanoma
Sulfonamides
Uveal Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Uveal Neoplasms

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PMID: 27928645
DOI: 10.1007/s00432-016-2317-y

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BRAF

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