Article
1,25D3 prevents CD8(+)Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter.
Nature communications - 11 Jan 2016
Schedel Michaela, Jia Yi, Michel Sven, Takeda Katsuyuki, Domenico Joanne, Joetham Anthony, Ning Fangkun, Strand Matthew, Han Junyan, Wang Meiqin, Lucas Joseph J, Vogelberg Christian, Kabesch Michael, O'Connor Brian P, Gelfand Erwin W
Abstract excerpt
Effector CD8(+) T cells convert from IFN-γ(+) (Tc1) to IL-13(+) (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion to IL-13-producers. Transfer of 1,25D3-treated CD8(+) T cells into sensitized and challenged CD8(+)-deficient...
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