Article
Association of vitamin D receptor gene polymorphisms with childhood and adult asthma.
American journal of respiratory and critical care medicine - 15 Nov 2004
Raby Benjamin A, Lazarus Ross, Silverman Edwin K, Lake Steven, Lange Christoph, Wjst Mathias, Weiss Scott T
Abstract excerpt
Vitamin D receptor (VDR) polymorphisms have been associated with several immune-related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to chromosome 12q, near a region commonly linked to asthma. We evaluated VDR as part of a 12q positional candidate survey, and in response to observations of VDR polymorphism associations with asthma and atopy in a founder population of Quebec....
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