Article
Analysis of HLA DR, HLA DQ, C4A, FcgammaRIIa, FcgammaRIIIa, MBL, and IL-1Ra allelic variants in Caucasian systemic lupus erythematosus patients suggests an effect of the combined FcgammaRIIa R/R and IL-1Ra 2/2 genotypes on disease susceptibility.
Arthritis research & therapy - 1 Jan 2004
Jönsen Andreas, Bengtsson Anders A, Sturfelt Gunnar, Truedsson Lennart
Abstract excerpt
Dysfunction in various parts of immune defence, such as immune response, immune complex clearance, and inflammation, has an impact on pathogenesis in systemic lupus erythematosus (SLE). We hypothesised that combinations of common variants of genes involved in these immune functions are associated with susceptibility to SLE. The following variants were analysed: HLA DR3, HLA DQ2, C4AQ0, Fcgamma receptor IIa...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antigens, CD
- Child
- Complement C4a
- Female
- Genetic Predisposition to Disease
- HLA-DQ Antigens