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Article

Leucine-rich repeat kinase 2 induces alpha-synuclein expression via the extracellular signal-regulated kinase pathway.

Cellular signalling - 1 May 2010

Carballo-Carbajal Iria, Weber-Endress Susanne, Rovelli Giorgio, Chan Diane, Wolozin Benjamin, Klein Christian L, Patenge Nadja, Gasser Thomas, Kahle Philipp J

Abstract excerpt

Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent cause of autosomal-dominant Parkinson's disease (PD). The second known autosomal-dominant PD gene (SNCA) encodes alpha-synuclein, which is deposited in Lewy bodies, the neuropathological hallmark of PD. LRRK2 contains a kinas...

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Identifiers

PMID: 20074637
DOI: 10.1016/j.cellsig.2010.01.006
PMCID: PMC3163153

Genes

SNCA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20074637-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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