Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.

Science (New York, N.Y.) - 12 Feb 2016

Branchfield Kelsey, Nantie Leah, Verheyden Jamie M, Sui Pengfei, Wienhold Mark D, Sun Xin

Abstract excerpt

The lung is constantly exposed to environmental atmospheric cues. How it senses and responds to these cues is poorly defined. Here, we show that Roundabout receptor (Robo) genes are expressed in pulmonary neuroendocrine cells (PNECs), a rare, innervated epithelial population. Robo inactivation in mouse lung results in an inability of PNECs to cluster into sensory organoids and triggers increased neuropeptide...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Lung
Share to Lung Diseases
Share to Macrophages

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Mutant Strains

Share to Nerve Tissue Proteins

Share to Neuropeptides

Share to Receptors, Immunologic

Share to Roundabout Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 26743624
DOI: 10.1126/science.aad7969
PMCID: PMC4860346

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pulmonary neuroendocrine cells function as airway sensors to control lung immune response.PMID 26743624Read ↗

Pulmonary neuroendocrine cells: physiology, tissue homeostasis and diseaseSemantic proximity Read ↗

Neuroendocrinology of the lung revealed by single cell RNA sequencingSemantic proximity Read ↗

RSV Promotes Epithelial Neuroendocrine Phenotype Differentiation through NODAL Signaling Pathway.Semantic proximity Read ↗

Transcriptome analysis reveals the impact of NETs activation on airway epithelial cell EMT and inflammation in bronchiolitis obliteransSemantic proximity Read ↗

Human pulmonary neuroendocrine cells respond to House dust mite extract with PAR-1 dependent release of CGRPSemantic proximity Read ↗

Functional characterization of pulmonary neuroendocrine cells in lung development, injury, and tumorigenesisSemantic proximity Read ↗

Disruption of E-cadherin in the airway led to dysplastic stressed cells and asthma-like phenotypes.Semantic proximity Read ↗

Shaping eosinophil identity in the tissue contexts of development, homeostasis, and diseaseSemantic proximity Read ↗

Epithelial reticulon 4B (Nogo-B) is an endogenous regulator of Th2-driven lung inflammationSemantic proximity Read ↗

Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein.Semantic proximity Read ↗

Chemosensory functions for pulmonary neuroendocrine cells.Semantic proximity Read ↗

Understanding the development of the respiratory glands.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.