Article
Differential regulation of translation and endocytosis of alternatively spliced forms of the type II bone morphogenetic protein (BMP) receptor.
Molecular biology of the cell - 15 Feb 2016
Amsalem Ayelet R, Marom Barak, Shapira Keren E, Hirschhorn Tal, Preisler Livia, Paarmann Pia, Knaus Petra, Henis Yoav I, Ehrlich Marcelo
Abstract excerpt
The expression and function of transforming growth factor-β superfamily receptors are regulated by multiple molecular mechanisms. The type II BMP receptor (BMPRII) is expressed as two alternatively spliced forms, a long and a short form (BMPRII-LF and -SF, respectively), which differ by an ∼500 amino acid C-terminal extension, unique among TGF-β superfamily receptors. Whereas this extension was proposed to...
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