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Article

Killed but metabolically active Bacillus anthracis vaccines induce broad and protective immunity against anthrax.

Infection and immunity - 1 Apr 2009

Skoble Justin, Beaber John W, Gao Yi, Lovchik Julie A, Sower Laurie E, Liu Weiqun, Luckett William, Peterson Johnny W, Calendar Richard, Portnoy Daniel A, Lyons C Rick, Dubensky Thomas W

Abstract excerpt

Bacillus anthracis is the causative agent of anthrax. We have developed a novel whole-bacterial-cell anthrax vaccine utilizing B. anthracis that is killed but metabolically active (KBMA). Vaccine strains that are asporogenic and nucleotide excision repair deficient were engineered by deleting the spoIIE and uvrAB genes, rendering B. anthracis extremely sensitive to photochemical inactivation with S-59 psoralen...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19168734
DOI: 10.1128/IAI.00530-08
PMCID: PMC2663168

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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