Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.

doi:10.1093/humrep/dev318

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Article

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.

Human reproduction (Oxford, England) - 1 Feb 2016

Ruth Katherine S, Beaumont Robin N, Tyrrell Jessica, Jones Samuel E, Tuke Marcus A, Yaghootkar Hanieh, Wood Andrew R, Freathy Rachel M, Weedon Michael N, Frayling Timothy M, Murray Anna

Abstract excerpt

STUDY QUESTION: How does a genetic variant in the FSHB promoter, known to alter FSH levels, impact female reproductive health? SUMMARY ANSWER: The T allele of the FSHB promoter polymorphism (rs10835638; c.-211G>T) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective against endometriosis. WHAT IS KNOWN ALREADY: The FSHB promoter polymorphism...

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Identifiers

PMID: 26732621
DOI: 10.1093/humrep/dev318
PMCID: PMC4716809

Genes

FSHB
MAF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.PMID 26732621Read ↗

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