Article

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank study

2015-10-01

Abstract excerpt

Study question: How does a genetic variant altering follicle stimulating hormone (FSH) levels, which we identified as associated with length of menstrual cycle, more widely impact reproductive health? <h4>Summary: </h4> answer: The T allele of the FSHB promoter polymorphism (rs10835638) results in longer menstrual cycles and later menopause and, while having detrimental effects on fertility, is protective agains...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1d240d55-acab-5074-bafb-672cf40db1ae
DOI: 10.1101/028001

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause, and impact reproductive health: a UK Biobank studyDOI 10.1101/028001Read

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health.Semantic proximity Read

FSHB -211 G>T is a major genetic modulator of reproductive physiology and health in childbearing age women.Semantic proximity Read

Genetic epistasis in FSH action influences female reproductive lifespan.Semantic proximity Read

Large-scale meta-analysis highlights the hypothalamic-pituitary-gonadal axis in the genetic regulation of menstrual cycle length.Semantic proximity Read

Mechanisms in endocrinology: Genetics of FSH action: a 2014-and-beyond view.Semantic proximity Read

A common single nucleotide polymorphism in exon 10 of the human follicle stimulating hormone receptor is a major determinant of length and hormonal dynamics of the menstrual cycle.Semantic proximity Read

FSHB promoter polymorphism within evolutionary conserved element is associated with serum FSH level in men.Semantic proximity Read

Effects of FSHR and FSHB Variants on Hormonal Profile and Reproductive Outcomes of Infertile Women With Endometriosis.Semantic proximity Read

Effect of the FSH receptor single nucleotide polymorphisms (FSHR 307/680) on the follicular fluid hormone profile and the granulosa cell gene expression in human small antral follicles.Semantic proximity Read

Pharmacogenetics of FSH Action in the FemaleSemantic proximity Read

Effects of the FSH-β-subunit promoter polymorphism -211G->T on the hypothalamic-pituitary-ovarian axis in normally cycling women indicate a gender-specific regulation of gonadotropin secretion.Semantic proximity Read

Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American womenSemantic proximity Read