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Article

Genetic epistasis in FSH action influences female reproductive lifespan.

Reproduction (Cambridge, England) - 5 Feb 2026

Kordes Gunnar P, Busch Alexander S

Abstract excerpt

Genetic factors significantly influence the timing of menarche and menopause, key markers defining the female reproductive lifespan. However, previous genetic studies have primarily focused on additive genetic models, overlooking potential gene-gene interactions ("epistasis"), particularly within critical hormonal pathways such as follicle-stimulating hormone (FSH) signaling. This study investigates epistasis...

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Topics

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Share to Epistasis, Genetic
Share to Follicle Stimulating Hormone
Share to Follicle Stimulating Hormone, beta Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Longevity

Share to Menstrual Cycle

Share to Polymorphism, Single Nucleotide

Share to Receptors, FSH

Share to Reproduction

Source

Identifiers

PMID: 41575282
DOI: 10.1093/reprod/xaag008

Genes

FSHB
FSHR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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