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Article

p21CDKN1A Regulates the Binding of Poly(ADP-Ribose) Polymerase-1 to DNA Repair Intermediates.

PloS one - 1 Jan 2016

Dutto Ilaria, Sukhanova Maria, Tillhon Micol, Cazzalini Ornella, Stivala Lucia A, Scovassi A Ivana, Lavrik Olga, Prosperi Ennio

Abstract excerpt

The cell cycle inhibitor p21CDKN1A was previously found to interact directly with DNA nick-sensor poly(ADP-ribose) polymerase-1 (PARP-1) and to promote base excision repair (BER). However, the molecular mechanism responsible for this BER-related association of p21 with PARP-1 remains to be clarified. In this study we investigate the capability of p21 to influence PARP-1 binding to DNA repair intermediates in a...

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Identifiers

PMID: 26730949
DOI: 10.1371/journal.pone.0146031
PMCID: PMC4701469

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Source receipt: pubmed, retrieved 7 Sept 2026.

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