Article

<i>In vitro</i> teratogenicity testing using a 3D, embryo-like gastruloid system

2021-03-30

Abstract excerpt

Pharmaceuticals that are intended for use in patients of childbearing potential need to be tested for teratogenicity before marketing. Several pharmaceutical companies use animal-free in vitro models which allow a more rapid selection of lead compounds and contribute to 3Rs principles (‘replace, reduce and refine’) by streamlining the selection of promising compounds that are submitted to further regulatory studi...

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Literature Corpus work: b9b49b2f-a381-5898-9e81-f40912ae4805
DOI: 10.1101/2021.03.30.437698

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