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Quantitative in vitro to in vivo extrapolation for developmental toxicity potency of valproic acid analogues

9 May 2022

Abstract excerpt

Abstract Background The developmental toxicity potential (dTP) concentration from the devTOX quickPredict (devTOXqP) assay, a metabolomics‐based human induced pluripotent stem cell assay, predicts a chemical's developmental toxicity potency. Here, in vitro to in vivo extrapolation (IVIVE) approaches were applied to address whether the devTOXqP assay could quantitatively predict in vivo developmental toxicity...

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PMID: 35532929
DOI: 10.1002/bdr2.2019

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