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Predictive Models of Prenatal Developmental Toxicity from ToxCast High-Throughput Screening Data

26 Aug 2011

Abstract excerpt

Environmental Protection Agency's ToxCast project is profiling the in vitro bioactivity of chemicals to assess pathway-level and cell-based signatures that correlate with observed in vivo toxicity. We hypothesized that developmental toxicity in guideline animal studies captured in the ToxRefDB database would correlate with cell-based and cell-free in vitro high-throughput screening (HTS) data to reveal meaningful...

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PMID: 21873373
DOI: 10.1093/toxsci/kfr220

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