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Article

Role of endothelial cells in pulmonary fibrosis via SREBP2 activation

21 Nov 2021

Abstract excerpt

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited treatment options. Despite endothelial cells (ECs) comprising 30% of the lung cellular composition, the role of EC dysfunction in pulmonary fibrosis (PF) remains unclear. We hypothesize that sterol regulatory element-binding protein 2 (SREBP2) plays a critical role in the pathogenesis of PF via EC phenotypic modifications....

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PMID: 34806652
DOI: 10.1172/jci.insight.125635

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