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Article

[Genetic heterogeneity in transient abnormal myelopoiesis].

[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Dec 2015

Saida Satoshi

Abstract excerpt

Leukemia arises through an evolutionary process of somatic mutation and selection. Transient abnormal myelopoiesis (TAM) is a clonal pre-leukemic disorder that progresses to myeloid leukemia of Down syndrome (ML-DS) through the accumulation of genetic alterations. To investigate the mechanism underlying leukemogenesis, a xenograft model of TAM was established using NOG mice. Serial engraftment after cell...

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Identifiers

PMID: 26725351
DOI: 10.11406/rinketsu.56.2434

Genes

GATA1
NOG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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