Article
Determination of BRCAness Phenotype in Breast Tumors for the Appointment of Neoadjuvant Chemotherapy Based on Platinum and Taxanes.
International journal of molecular sciences - 22 Dec 2022
Tsyganov Matvey Mihajlovich, Ibragimova Marina K, Garbukov Evgeniy Y, Bragina Olga D, Karchevskaya Ariana A, Usynin Evgeny A, Litvyakov Nikolai V
Abstract excerpt
The concept of BRCAness was developed because of similarities between sporadic and hereditary breast cancer. BRCAness defines the pathogenesis and treatment sensitivity of many types of cancer, as well as the presence of a defect in the homologous recombination repair of tumor cells simulating the loss of BRCA1 or BRCA2, as in the presence of germline mutations. The question of treatment effectiveness for...
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