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Article

Mutational profiling of familial male breast cancers reveals similarities with luminal A female breast cancer with rare TP53 mutations.

British journal of cancer - 9 Dec 2014

Deb S, Wong S Q, Li J, Do H, Weiss J, Byrne D, Chakrabarti A, Bosma T, Fellowes A, Dobrovic A, Fox S B

Abstract excerpt

BACKGROUND: Male breast cancer (MBC) is still poorly understood with a large proportion arising in families with a history of breast cancer. Genomic studies have focused on germline determinants of MBC risk, with minimal knowledge of somatic changes in these cancers. METHODS: Using a TruSeq amplicon cancer panel, this study evaluated 48 familial MBCs (3 BRCA1 germline mutant, 17 BRCA2 germline mutant and 28...

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Topics

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Share to BRCA1 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms, Male

Share to DNA Mutational Analysis

Share to Genes, p53

Share to High-Throughput Nucleotide Sequencing

Share to PTEN Phosphohydrolase

Share to Tumor Suppressor Protein p53

Source

Open in PubMed Open full text

Identifiers

PMID: 25490678
DOI: 10.1038/bjc.2014.511
PMCID: PMC4264438

Genes

BRCA2
PTEN
HRAS
SMARCB1
STK11
ABL1
ATM
BRCA1
GNAQ
GNAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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