Article
The PrP-like proteins Shadoo and Doppel.
Topics in current chemistry - 1 Jan 2011
Westaway David, Daude Nathalie, Wohlgemuth Serene, Harrison Paul
Abstract excerpt
An almost unique place within protein databases, twenty-five years of study has underscored the enigmatically subtle role of PrP(C) in normal cell biology. It seems that PrP has evolved (and survived) to perform a function that does not have a precedent amongst transmembrane cell-surface proteins, perhaps representing a new type of plasma membrane ecosystem. In a context where we await a clarifying insight to...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Biophysics
- Cell Membrane
- GPI-Linked Proteins
- Humans
- Models, Biological
- Molecular Sequence Data
- Nerve Tissue Proteins
- Neurons
- Polymorphism, Genetic