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Article

Normal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue Doppel.

EMBO reports - 1 Apr 2001

Behrens A, Brandner S, Genoud N, Aguzzi A

Abstract excerpt

The agent that causes prion diseases is thought to be identical to PrPSc, a conformer of the normal prion protein PrPC. Recently a novel protein, termed Doppel (Dpl), was identified that shares significant biochemical and structural homology with PrPC. To investigate the function of Dpl in neurogenesis and in prion pathology, we generated embryonic stem (ES) cells harbouring a homozygous disruption of the Prnd...

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Identifiers

PMID: 11306558
DOI: 10.1093/embo-reports/kve088
PMCID: PMC1083878

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Source receipt: pubmed, retrieved 7 Sept 2026.

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