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Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanism

2025-05-13

Abstract excerpt

The human developmental disorder 3MC syndrome is characterized by skeletal deformities associated with a deficiency of the pattern recognition molecule collectin-11 (CL-11), yet the underlying molecular and cellular mechanisms remain unclear. Here, we demonstrate that CL-11 deletion alone does not cause bone abnormalities in mice; however, combined deficiencies involving CL-11 and complement components MASP-2 (lec...

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Literature Corpus work
248cfc0c-4aea-5a3c-a480-98dcad5b8585
DOI
10.1101/2025.05.08.652605
Open publication

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Collectin-11 regulates osteoclastogenesis and bone maintenance via a complement-dependent mechanismDOI 10.1101/2025.05.08.652605
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