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Article

Functional analysis of acquired CD28 mutations identified in cutaneous T cell lymphoma.

Cellular immunology - 1 Sept 2017

Gmyrek Grzegorz B, Pingel Jeanette, Choi Jaehyuk, Green Jonathan M

Abstract excerpt

CD28 is the major costimulatory receptor on T cells regulating proliferation, survival and effector function. Acquired mutations in the extracellular domain of CD28 have been identified in patients with cutaneous T cell lymphoma, angioimmunoblastic T cell lymphoma and other T cell neoplasms, suggesting it may contribute to disease pathogenesis. We used a heterologous system in which mutant human CD28 was...

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Share to CD28 Antigens
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Lymphoma, T-Cell, Cutaneous

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Source

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Identifiers

PMID: 28711152
DOI: 10.1016/j.cellimm.2017.07.002
PMCID: PMC5667648

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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