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Article

Activating mutations in genes related to TCR signaling in angioimmunoblastic and other follicular helper T-cell-derived lymphomas.

Blood - 15 Sept 2016

Vallois David, Dobay Maria Pamela D, Morin Ryan D, Lemonnier François, Missiaglia Edoardo, Juilland Mélanie, Iwaszkiewicz Justyna, Fataccioli Virginie, Bisig Bettina, Roberti Annalisa, Grewal Jasleen, Bruneau Julie, Fabiani Bettina, Martin Antoine, Bonnet Christophe, Michielin Olivier, Jais Jean-Philippe, Figeac Martin, Bernard Olivier A, Delorenzi Mauro, Haioun Corinne, Tournilhac Olivier, Thome Margot, Gascoyne Randy D, Gaulard Philippe, de Leval Laurence

Abstract excerpt

Angioimmunoblastic T-cell lymphoma (AITL) and other lymphomas derived from follicular T-helper cells (TFH) represent a large proportion of peripheral T-cell lymphomas (PTCLs) with poorly understood pathogenesis and unfavorable treatment results. We investigated a series of 85 patients with AITL (n = 72) or other TFH-derived PTCL (n = 13) by targeted deep sequencing of a gene panel enriched in T-cell receptor...

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Source

Identifiers

PMID: 27369867
DOI: 10.1182/blood-2016-02-698977

Genes

PLCG1
RHOA
CARD11
CTNNB1
MALT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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