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Article

Complex analysis of the p53 tumor suppressor in lung carcinoma.

Oncology reports - 1 Mar 2016

Smardova Jana, Liskova Kvetoslava, Ravcukova Barbora, Malcikova Jitka, Hausnerova Jitka, Svitakova Miluse, Hrabalkova Renata, Zlamalikova Lenka, Stano-Kozubik Katerina, Blahakova Ivona, Speldova Jana, Jarkovsky Jiri, Smarda Jan

Abstract excerpt

Lung cancer is the leading cause of cancer-related deaths worldwide. The p53 tumor suppressor is a transcription factor controlling expression of its target genes in response to various stress stimuli. Mutations of the TP53 gene occur very frequently in lung carcinomas and they play an important role in both oncogenic transformation of lung epithelial cells and lung carcinoma progression. We determined the TP53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

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Identifiers

PMID: 26718964
DOI: 10.3892/or.2015.4533

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