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Article

Assessment of p53 functional activity in tumor cells and histologically normal mucosa from patients with head and neck squamous cell carcinoma.

Head & neck - 1 Nov 2012

Van der Vorst Sébastien, Dekairelle Anne-France, Weynand Birgit, Hamoir Marc, Gala Jean-Luc

Abstract excerpt

BACKGROUND: The purpose of this study was to investigate the value of p53 functional analysis of separated alleles in yeast (FASAY) as a witness of p53/p21 pathway alteration in head and neck squamous cell carcinoma (HNSCC). METHODS: The p53 transcriptional activity was prospectively analyzed in 82 newly diagnosed patients with HNSCC. FASAY and p53 immunostaining were carried out on paired tumoral and...

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Share to Carcinoma, Squamous Cell
Share to Head and Neck Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mucous Membrane

Share to Neoplasm Recurrence, Local

Share to Squamous Cell Carcinoma of Head and Neck

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 22109999
DOI: 10.1002/hed.21960

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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