Article
A genome-wide association study suggests new evidence for an association of the NADPH Oxidase 4 (NOX4) gene with severe diabetic retinopathy in type 2 diabetes.
Acta ophthalmologica - 1 Nov 2018
Meng Weihua, Shah Kaanan P, Pollack Samuela, Toppila Iiro, Hebert Harry L, McCarthy Mark I, Groop Leif, Ahlqvist Emma, Lyssenko Valeriya, Agardh Elisabet, Daniell Mark, Kaidonis Georgia, Craig Jamie E, Mitchell Paul, Liew Gerald, Kifley Annette, Wang Jie Jin, Christiansen Mark W, Jensen Richard A, Penman Alan, Hancock Heather A, Chen Ching J, Correa Adolfo, Kuo Jane Z, Li Xiaohui, Chen Yii-der I, Rotter Jerome I, Klein Ronald, Klein Barbara, Wong Tien Y, Morris Andrew D, Doney Alexander S F, Colhoun Helen M, Price Alkes L, Burdon Kathryn P, Groop Per-Henrik, Sandholm Niina, Grassi Michael A, Sobrin Lucia, Palmer Colin N A
Abstract excerpt
PURPOSE: Diabetic retinopathy is the most common eye complication in patients with diabetes. The purpose of this study is to identify genetic factors contributing to severe diabetic retinopathy. METHODS: A genome-wide association approach was applied. In the Genetics of Diabetes Audit and Research in Tayside Scotland (GoDARTS) datasets, cases of severe diabetic retinopathy were defined as type 2 diabetic patients...
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