Adaptive selection at G6PD and disparities in diabetes complications.

doi:10.1038/s41591-024-03089-1

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Article

Adaptive selection at G6PD and disparities in diabetes complications.

Nature medicine - 1 Sept 2024

Breeyear Joseph H, Hellwege Jacklyn N, Schroeder Philip H, House John S, Poisner Hannah M, Mitchell Sabrina L, Charest Brian, Khakharia Anjali, Basnet Til B, Halladay Christopher W, Reaven Peter D, Meigs James B, Rhee Mary K, Sun Yang, Lynch Mary G, Bick Alexander G, Wilson Otis D, Hung Adriana M, Nealon Cari L, Iyengar Sudha K, Rotroff Daniel M, Buse John B, Leong Aaron, Mercader Josep M, Sobrin Lucia, Brantley Milam A, Peachey Neal S, Motsinger-Reif Alison A, Wilson Peter W, Sun Yan V, Giri Ayush, Phillips Lawrence S, Edwards Todd L

Abstract excerpt

Diabetes complications occur at higher rates in individuals of African ancestry. Glucose-6-phosphate dehydrogenase deficiency (G6PDdef), common in some African populations, confers malaria resistance, and reduces hemoglobin A1c (HbA1c) levels by shortening erythrocyte lifespan. In a combined-ancestry genome-wide association study of diabetic retinopathy, we identified nine loci including a G6PDdef causal variant,...

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Identifiers

PMID: 38918629
DOI: 10.1038/s41591-024-03089-1
PMCID: PMC11555759

Genes

G6PD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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