Article
Genome-wide association study of retinopathy in individuals without diabetes.
PloS one - 1 Jan 2013
Jensen Richard A, Sim Xueling, Li Xiaohui, Cotch Mary Frances, Ikram M Kamran, Holliday Elizabeth G, Eiriksdottir Gudny, Harris Tamara B, Jonasson Fridbert, Klein Barbara E K, Launer Lenore J, Smith Albert Vernon, Boerwinkle Eric, Cheung Ning, Hewitt Alex W, Liew Gerald, Mitchell Paul, Wang Jie Jin, Attia John, Scott Rodney, Glazer Nicole L, Lumley Thomas, McKnight Barbara, Psaty Bruce M, Taylor Kent, Hofman Albert, de Jong Paulus T V M, Rivadeneira Fernando, Uitterlinden Andre G, Tay Wan-Ting, Teo Yik Ying, Seielstad Mark, Liu Jianjun, Cheng Ching-Yu, Saw Seang-Mei, Aung Tin, Ganesh Santhi K, O'Donnell Christopher J, Nalls Mike A, Wiggins Kerri L, Kuo Jane Z, van Duijn Cornelia M, Gudnason Vilmundur, Klein Ronald, Siscovick David S, Rotter Jerome I, Tai E Shong, Vingerling Johannes, Wong Tien Y
Abstract excerpt
BACKGROUND: Mild retinopathy (microaneurysms or dot-blot hemorrhages) is observed in persons without diabetes or hypertension and may reflect microvascular disease in other organs. We conducted a genome-wide association study (GWAS) of mild retinopathy in persons without diabetes. METHODS: A working group agreed on phenotype harmonization, covariate selection and analytic plans for within-cohort GWAS. An...
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