Article
Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes.
Diabetes - 1 Nov 2011
Syreeni Anna, El-Osta Assam, Forsblom Carol, Sandholm Niina, Parkkonen Maikki, Tarnow Lise, Parving Hans-Henrik, McKnight Amy J, Maxwell Alexander P, Cooper Mark E, Groop Per-Henrik
Abstract excerpt
OBJECTIVE: Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications often persist and progress despite improved glucose control, possibly as a result of prior episodes of hyperglycemia. Epigenetic modifications mediated by histone methyltransferases are associated...
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